PHARM.D

Dear friends, PHARMD FUND TEAM WISHES YOU A VERY HAPPY AND SAFE DIWALI. THIS DIWALI SHOULD BRING GOODNESS OF LIGHTS IN YOUR LIFE. Friends our humble request to you is that use only eco friendly crackers use Diyas (EARTHEN LAMPS) made of sandy material use cotton clothes Do not use any noisey fire works as it causes sound pollution. If you are using crackers keep a bucket full of water near you so that if some burn happens immediately insert in the water and do not apply any oils or creams to the burns and consult your doctor immediately. Wash the hands thoroughly. Do not use any crackers near the hospitals "LET US SAVE OUR EARTH FROM POLLUTION AND MAKE THE EARTH POLLUTION FREE" "LET US MINIMISE THE POISONOUS EFFECT OF CRACKER AND MAXIMISE THE HAPPINESS WITH EARTHEN LAMPS"                                  ...

FDA Updates Warnings on Methylene Blue, Linezolid, and Serotonergics The US Food and Drug Administration (FDA) has fine-tuned a warning issued in July to avoid prescribing either methylene blue or linezolid ( Zyvox , Pfizer) in combination with serotonergic agents because of the potential to cause serotonin syndrome. Today, the FDA announced that the risk for this harmful interaction appears to be confined, in general, to 2 specific types of serotonergic drugs: selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors. Methylene blue is a dye used in diagnostic procedures and in the treatment of conditions ranging from cyanide poisoning to methemoglobinemia. Linezolid is an antibacterial agent. Both drugs inhibit the action of monoamine oxidase A, an enzyme that breaks down serotonin. This allows the levels of the neurotransmitter to ...

FDA Approvals: Infliximab for Pediatric Ulcerative Colitis Clinical Context The US Food and Drug Administration (FDA) approved infliximab ( Remicade , Janssen Biotech) to treat moderately to severely active ulcerative colitis (UC) in children older than 6 years who have not responded adequately to conventional therapy. Infliximab is an immune system modulator that blocks the activity of tumor necrosis factor (TNF)-α, which causes inflammation and triggers autoimmune diseases. The FDA has previously approved infliximab to treat adults with UC, and adults and children older than 6 years with Crohn's disease. It is also indicated for rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and plaque psoriasis in adults. The FDA has now extended the UC indication to children older than 6 years. Study Synopsis and Perspective The FDA approved infliximab ( Remicade , Janssen Biotech) to treat moderately to severely active UC in children older than 6 years who ha...

Manufacture, Sale and Distribution of Letrozole Suspended In exercise of the powers conferred by section 26A of the Drugs and Cosmetic Act, 1940 (23 of 1940), the Central Government has suspended the manufacture for sale, sale and distribution of ‘Letrozole for induction of ovulation in anovulatory infertility’ with immediate effect.   The Central Government is satisfied that it is necessary and expedient to regulate by way of suspension of manufacture, sale and distribution of the drug for the said indication in the public interest.   The Central Government is satisfied that the use of the drug letrozole for induction of ovulation in anovulatory infertility is likely to involve risk to human beings and safer alternatives to the said drugs are available.   SBS/ls   (Release ID :76709) REFERENCE:   http://pib.nic.in/newsite/erelease.aspx?relid=76709

Enzyme offers hope in tackling autoimmune disorders: expert The Hindu  (From left) A.N. Malaviya, former professor of Medicine and chief of Clinical Immunology and Rheumatology, All India Institute of Medical Science, New Delhi, S. Rangamani, Vice Chancellor of Sri Ramachandra University and S.P. Thyagarajan, Pro-Chancellor (Research), at an endowment oration in Chennai on Saturday. Photo: S.S. Kumar Enzyme IDO effective against disorder: A.N. Malaviya Ongoing research on an enzyme, IDO, has shown a lot of promise in being able to treat autoimmune disorders, A.N. Malaviya, former Professor and Head of Medicine and chief of Clinical Immunology and Rheumatology Services, All India Institute of Medical Sciences, New Delhi, said. IDO, which is present in the peripheral mechanism, is likely to emerge as the drug for the future to control autoimmune diseases, Dr. Malaviya explained. Further research would have to validate these initial results. Auto immune disorders are caused when the...

Multivitamin use and breast cancer incidence in a prospective cohort of   Swedish women Susanna C Larsson, Agneta A kesson, Leif Bergkvist, and Alicja Wolk ABSTRACT Background: Many women use multivitamins in the belief that these supplements will prevent chronic diseases such as cancer and cardiovascular disease. However, whether the use of multivitamins affects the risk of breast cancer is unclear. Objective: We prospectively examined the association between multivitamin use and the incidence of invasive breast cancer in The Swedish Mammography Cohort. Design: In 1997, 35,329 cancer-free women completed a self administered questionnaire that solicited information on multivitamin use as well as other breast cancer risk factors. Relative risks (RRs) and 95% CIs were calculated by using Cox proportional hazard models and adjusted for breast cancer risk factors. Results: During a mean follow-up of 9.5 y, 974 women were diagnosed with incident breast cancer. Multivitamin use...

FDA approves combination therapy Juvisync First combination drug to treat type 2 diabetes and high cholesterol in one tablet The U.S. Food and Drug Administration today approved Juvisync (sitagliptin and simvastatin), a fixed-dose combination (FDC) prescription medication that contains two previously approved medicines in one tablet for use in adults who need both sitagliptin and simvastatin. About 20 million people in the United States have type 2 diabetes, and they often have high cholesterol levels as well. These conditions can lead to increased risk of heart disease, stroke, kidney disease and blindness, among other chronic conditions, particularly if left untreated or poorly treated. Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor that enhances the body's own ability to lower elevated blood sugar and is approved for use in combination with diet and exercise to improve glycemic control in adults with type 2 diabetes. Simvastatin is an HMG-CoA r...

ipc conference 2011 at manipal

  Hai friends this is an article from andhra pradesh states leading news paper about pharmacy courses in andhra pradesh .click on the image to view it large courtesy:www.eenadu.net/chaduvu(29/8/2011)

                      yellow phosphorous poisoning yellow phosphorous was once used as a rat or roach poison . Fire works and fertilizers manufactures which release phosphine on contact with water. DOSE: The fatal dose of yellow phosphorous or phosphite is approximatyely 1mg/kg. The exposure limit for yellow phosphorous is 0.1 mg/m3; for phosphine , 0.3 ppm;and for phenyl phosphine,0.05ppm. Symptoms: phosphorous causes tissue destruction , with disturbanxce in carbohydrate, fat, protein metabolism in the liver. Deposition ofglycogen in liver is inhibited; deposition of fat is increased. Chronic absorption of phosphorous increases bone formation under the epiphyseal cartilage and impairs blood circulation in bone by bone formation in haverian and marrow canals. These changes lead to necrosis and sequestration of bone; they occur most frequentlyu in the mandible. The pathologic findings in yellow phosphorous pois...

Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo. The anti-leprosy drug Clofazimine is known to inhibit respiratory function and hence energy metabolism in yeast and in transformed fibroblasts. The aim of this study was to examine the effect of Clofazimine on the energy metabolism of a chemoresistant human non-small-cell bronchial-carcinoma cell line (WIL) and to determine whether this agent might inhibit the growth rate of this cell line in vitro and in vivo. Oxidative phosphorylation was estimated in vitro by measuring oxygen consumption polarographically and glycolysis was estimated from lactate production. In cells that had been pre-treated with an ATP synthetase inhibitor (oligomycin), the addition of Clofazimine resulted in an increase in oxygen consumption similar to that observed with 2,4-dinitrophenol, a classical inhibitor of oxidative phosphorylation. This inhibition of mitochondrial function was ass...

Hai friends when we get any cold or cough we prefer to use our own remidies or the known medications and antibiotics.when it doesnot works we will consult a doctor and he will prescribe antibiotics for about five days or one week. But most of the patients do not complete the prescribed duration and they will not take any antibiotics after they feel that they have cured. But remember when a doctor prescribe it for five or one week we should complete the course of duration of the drug . Because when we use the two days we feel better. But when we leave the usage of drug the bacteria or virus gets resistance to  that drug and it may cause severe problems. So when a doctor prescribes you with an antibiotic use it for the prescribed days so that the disease can be cured completely. If you have any complaints or any side effects regarding the drugs consult your prescribed doctor immediately.                           ...

                         SAVE NATURE In today's life the most dangerous and  threatening thing in the world is " GLOBAL WARMING" According to a survey the temperature in the earth is increasing day by day. And also the poles are melting and the water content on the earth is increasing day by day. But due to the increase in water content the land area will be decreased and it leads to less space on earth. This " GLOBAL WARMING " is because of our needs we have caused dangerous harm to the earth. So the nature cannot tolerate and one day it is going to show the result which will be so serious that I and you cannot expect. Dear people wake up so that its time to recover and save the earth and remove the word " GLOBAL WARMING" in future. Save trees and agricultural lands   Stop terror on the earth Say no to plastic Recycle the waste electronic goods...

SAVE NATURE FROM POLLUTING SMALL SCALE COMPANIES June -26 -2011 - Hai friends many small scale companies are running their industreis without proper infrastructure . what ever the waste that is produced from the factory they are flushing it in to the agricultural fields will makes loss of fertility to the soil and those lands cannot be used for agriculture. so the agricultural land becomes infertile . this pictures has been taken while travelling through the train . How the industries making mischief to the lands If they can, do any thing they can use water filtering plants through which the flushed water can be filtered and reused and need not be flush the water to the poor agricultural lands. If they can, they can reduce the pollution by planting more trees which will take the carbondi oxide and release pure oxygen to us Please think we have lot of oppurtunities to do many good things to the nature. Be a responsible human being and use accurate measures to save the...

FDA Approves First Generic Versions of Levofloxacin Tinker Ready The US Food and Drug Administration (FDA) yesterday approved applications from 12 companies to manufacture generic versions of levofloxacin ( Levaquin , Ortho-McNeil-Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson), a widely used fluoroquinolone antibiotic. The companies, including Teva Pharmaceutical and Sandoz Inc, will start producing generic levofloxacin now that Johnson & Johnson's patent has expired. The drug has been a blockbuster for the company. In the United States, Levaquin had sales of $1.3 billion in 2010 and $422 million in the first quarter of 2011, according to news sources. Levofloxacin is the second common drug in its class to become available in generic form. Another fluoroquinolone, ciprofloxacin ( Cipro , Bayer) is also available generically. The patent for a third drug in the same class, moxifloxacin ( Avelox , Schering Corp, a subsidiary of Merck & Co), expir...

FDA Approves Tamper-Resistant Oxycodone Susan Jeffrey  Pfizer Inc and Acura Pharmaceuticals Inc announced today marketing approval from the US Food and Drug Administration (FDA) for a new formulation of oxycodone hydrochloride (HCl), USP tablets ( Oxecta ) CII. The new formulation is indicated for the management of acute and chronic moderate to severe pain when the use of an opioid analgesic is appropriate. The product is an immediate-release oxycodone medication that applies technology designed to discourage common methods of tampering associated with opioid abuse and misuse, the companies said in a statement. This technology, known as Aversion Technology , uses commonly available pharmaceutical ingredients that, for example, cause the active ingredient to gel to prevent injection or to irritate nasal passages to discourage inhalation. Pfizer is licensing the technology in this product from Acura . "Opioid medications are an important treatment option for patients with modera...

Breast-Feeding Lowers Risk for Sudden Infant Death Syndrome Laurie Barclay, MD Breast-feeding, particularly exclusive breast-feeding, is associated with a lower risk for sudden infant death syndrome (SIDS) according to the results of a  meta-analysis  reported online June 13 in  Pediatrics . "Benefits of breastfeeding include lower risk of postneonatal mortality," write Fern R. Hauck, MD, MS, from the Department of Family Medicine, University of Virginia School of Medicine in Charlottesville, and colleagues. "However, it is unclear whether breastfeeding specifically lowers ...SIDS risk, because study results have been conflicting." The goal of this meta-analysis was to evaluate the relationship between breast-feeding and SIDS. A Medline search from 1966 to 2009, as well as a search of bibliographies of review articles and meta-analyses, identified 288 studies with data on breast-feeding and SIDS. Of 24 original case-control studies examining the association betw...

                                                                      BANNED DRUGS A number of individual drugs as well as fixed  dose  combinations are banned in India. Drugs undergo rigorous  testing  before they are introduced into the market. They are first tested in animals and then in human beings during clinical trials.  The efficacy as well as  safety  profiles  of the drug are tested.   In spite of this, some adverse effects of drugs appear only after the drug is used in the general population.  These adverse effects are detected though a process of regular monitoring after the drug is released called  pharmacovigilance .  If the adverse effects are severe or the risks of using the drug outweigh the benefits, or if the drug is ineffec...